The International Institute
of Molecular Mechanisms and Machines
Polish Academy of Sciences
PHD STUDENT
„Structure-function analysis of the spliceosome”
Laboratory of RNA Biology,
Head: Magda Konarska
POSITION IN PROJECT
PhD student
SCIENTIFIC DISCIPLINE
structural biology, molecular biology, biochemistry,
NUMBER OF JOB OFFERS
1
JOB TYPE
Full-time position, stipend
REMUNERATION (PLN/MONTH)
3 500,00 – 4 000,00 PLN net; depending on experience
POSITION STARTS ON
ASAP
PROJECT TITLE
"Regenerative Mechanisms for Health" ReMedy
APPLICATION DEADLINE
19th May 2021
PROJECT LEADER
Magda Konarska
PROJECT DESCRIPTION
We are interested in the function of the spliceosome and in its dynamic changes during splicing, and possibly in response to stress conditions. The spliceosomal catalytic center undergoes dynamic changes during the catalytic phase of splicing; these changes affect splicing catalysis, altering splicing fidelity and thus affecting alternative splicing patterns. Using recent cryo-EM information of yeast S. cerevisiae spliceosome as a model, we focus on substrate-spliceosome interactions at the catalytic center. These studies will lead to new approaches for modulating alternative splicing patterns.
YOUR FUTURE KEY RESPONSIBILITIES:
Performing experiments using biochemical, structural and molecular biology techniques (independently and in collaboration with other team members),
Participation in experimental design and data analysis,
Participation in the data preparation and writing of manuscripts,
Active participation in lab meetings, scientific seminars and conferences.
IF YOU ARE:
MSc degree (or equivalent) in molecular biology, biophysics, biochemistry or related fields of life sciences (or perspective of obtaining one),
Solid knowledge and familiarity with laboratory techniques in at least one of the following disciplines: molecular biology, biochemistry, cell biology, genetics, transcriptomics,
Very good command of English,
Motivation and passion for experimental work.
... PLEASE APPLY.
And let us present the details to you.
REQUIRED DOCUMENTS
(EN ONLY)
Motivation letter,
CV with the list of publications,
Contact details of the scientific supervisor and other referee/s if available (preferably including direct supervisor of applicant’s MSc thesis).
We will contact selected candidates only.
FNP PROGRAMME
Project is carried out within the International Research Agendas Programme of the Foundation for Polish Science
SEND APPLICATION
PhD Student
Project: „Structure-function analysis of the spliceosome”
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